- What causes Paget’s disease?
- How is Paget’s disease diagnosed and treated?
- Does Paget’s disease hurt?
- Which is the first line treatment for Paget’s disease?
- Is Paget’s disease benign or malignant?
- Is Paget’s disease genetic?
- Is Paget’s disease serious?
- Is Paget’s disease curable?
- Is Paget’s disease autoimmune?
- What is the prognosis for Paget disease?
- What are the stages of Paget disease?
- What is the most common age for females to be diagnosed with Paget’s disease?
What causes Paget’s disease?
The exact cause of Paget’s disease is unknown.
Researchers speculate that the cause of the disorder may be multifactorial (e.g.
caused by the interaction of certain genetic and environmental factors).
In most cases, no specific cause for Paget’s disease can be identified (sporadic)..
How is Paget’s disease diagnosed and treated?
During the physical exam, your doctor will examine areas of your body that are causing you pain. He or she may also order X-rays and blood tests that can help confirm the diagnosis of Paget’s disease of bone.
Does Paget’s disease hurt?
Symptoms of Paget’s disease of bone include bone pain, joint pain and problems caused by a nerve being squashed or damaged. But in many cases, there are no obvious symptoms and the condition is only found during tests carried out for another reason. 1 bone or several bones may be affected.
Which is the first line treatment for Paget’s disease?
Bisphosphonates are first-line therapy for Paget’s disease, and the advent of the new bisphosphonates permits a dramatic improvement in treatment. The optimal treatment regimen should obtain normalisation or quasi-normalisation of markers of bone remodelling.
Is Paget’s disease benign or malignant?
The initial skin changes of Paget’s disease of the breast may appear relatively benign and many individuals may overlook such symptoms, mistakenly attributing them to an inflammatory skin condition or infection. As a result, diagnosis may be delayed, often up to six months or more.
Is Paget’s disease genetic?
Mutations in the SQSTM1 gene are the most common genetic cause of classic Paget disease of bone, accounting for 10 to 50 percent of cases that run in families and 5 to 30 percent of cases in which there is no family history of the disease.
Is Paget’s disease serious?
Paget’s disease of bone can sometimes lead to further, potentially serious problems. These include: fragile bones that break more easily than normal. enlarged or misshapen bones.
Is Paget’s disease curable?
There’s currently no cure for Paget’s disease of bone, but treatment can help relieve the symptoms.
Is Paget’s disease autoimmune?
Paget’s disease of bone is a chronic autoimmune inflammatory disease that leads to an increase in bone reabsorption. While depression is extensively described in Paget’s disease, affecting up to 50% of patients, the prevalence of manic episodes is unknown.
What is the prognosis for Paget disease?
The 5-year survival rate for a patient with Paget disease and sarcoma is 5-7.5%; however, it may be as high as 50% for those who undergo operative tumor ablation and chemotherapy before metastases occur. The 5-year survival rate for elderly patients with primary nonpagetic sarcoma is 37%.
What are the stages of Paget disease?
Three phases of Paget disease have been described: lytic, mixed lytic and blastic, and sclerotic. In an individual patient, different skeletal lesions may progress at different rates. Thus, at any one time, multiple stages of the disease may be demonstrated in different skeletal regions.
What is the most common age for females to be diagnosed with Paget’s disease?
Paget’s disease of the breast occurs most often in women older than age 50. Most women with Paget’s disease of the breast have underlying ductal breast cancer, either in situ — meaning in its original place — or, less commonly, invasive breast cancer.